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KMID : 0043319980210030266
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Archives of Pharmacal Research
1998 Volume.21 No. 3 p.266 ~ p.272
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Antitumor Activity of the Aqueous-alcoholic Extracts from Unripe Cotton Ball of Gossypium indicum
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Choi Jung-Jin
Yoon Keum-Na
Lee Seung-Ki
Lee Yong-Hee
Park Jeong-Hill
Kim Wang-Yu
Kim Joon-Kyum
Kim Won-Ki
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Abstract
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The present study investigated the antitumor activity of the aqueous-alcoholic extracts from unripe cotton balls of Gossypium indicum. An Exposure of murine B16 melanoma and L1210 lymphoma cells to the extracts resulted in their severe deaths in time- and concentration-dependent manners. Of the extracts, hydrophilic fractions were most efficacious for the antitumor activity and found to contain certain amounts of catechin and its derivatives. The hydrophilic extract fraction C36B2-8 had approximately 10 times more cytotoxic effects on B12 and L1210 cells than on isolated murine thymocytes. High concentrations (>150 g/ml) of C 36B3-8 mainly induced necrotic cell death. At low concentrations (<100 g/ml), however, C 36B3-8 induced not only necrosis but also apoptosis of the two tumor cell lines, which was proved by the TUNEL staining and DNA fragmentation techniques. The data indicate that certain ingredients of the cotton ball extract of G. indicum have an antitumor activity.
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KEYWORD
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Gossypium indicum, Cotton ball, Anticancer activity, Aprptosis, Necrosis, B16 melanoma, L1210 leukemia, Thymocytes
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